NURS 735 - APPLIED TOXICOLOGY
Module 2: Principles of Absorption, Distribution, Metabolism and Excretion

 CHILDRENS' SUSCEPTIBILITIES
Guest Contributor: LIZ BLACKBURN, US Environmental Protection Agency

'Why kids are different than little adults with regard to ADME principles.


Liz Blackburn, US Environmental Protection Agency
Support materials: [Figure 1] [Figure 2] [Table 1] [Figure 3]

 

SUPPLEMENTAL READINGS:

How are children different from adults? (Bearer-EHP1995)

And related US EPA publications:

Vulernability and health problems in children

Critical periods in development

Children's environmental exposures

 

 

 


 

 

Figure 1. Pesticide air concentrations in child and adult breathing zones in a ventilated room. The concentrations of a pesticide are much higher in the breathing zone of a child than of an adult, even 24 hours after the pesticide is applied. Thus, children may have a greater exposure to pesticides applied around the house than adults do. [Back to movie]

 


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Figure 2. Average food consumption by age. [Back to movie]

 


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 Table 1. Stages of prenatal and postnatal organ structural development.
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 Organ System

Early Prenatal

Mid-Late Prenatal

Postnatal
 CNS

 3-16 weeks

 17-40 weeks
 Continues into adulthood
 Ear

 4-16 weeks

 17-20 weeks
 ---
Heart

3-8 weeks

 ---
  ---
 Immune system

 8-16 weeks

 17-40 weeks
Immunocompentence: 0-1+ years
Immune memory: 1-18 years
 Kidneys

 4-16 weeks

 17-40 weeks
 Nephrons mature in outer cortical region, providing ability to concentrate urine
 Limbs

 4-8 weeks

 ---
 ---
 Lungs

 3-16 weeks

 17-40 weeks
 > 80% of alveoli are formed after birth to age 8-10
 Palate

 6-10 weeks

 ---
 ---
 Reproductive system

 7-9 weeks

 10-40 weeks
Sexual maturation; breast and cervix development: 9-16 years
 Skeleton

 1-2 weeks

 ---
Ossification continues for ~25 years
 Teeth

 12-16 weeks

 17-24+ weeks
Primary dentition: 4 months after conception to 3 years postnatal.
Permanent dentition: 3 months after birth to 25 years. 


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Figure 3. Half-life results for caffeine and theophylline. Note, half-life of theophylline increases again in adolescence, possibly due to competition with steroid hormones. [Back to movie]

 


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