NURS 735 - APPLIED TOXICOLOGY

Developmental toxicology encompasses the study of pharmacokinetics, mechanisms, pathogenesis, and ou8tcome following expousre to agents or conditions leading to abnormal development. Manifestations of developmental toxicity include structural malformations, growth retardation, functional impairment, and/ or death of an organism. This module will review different types of exposures and mechanistic effects associated with developmental toxicity that may occur during susceptible periods of fetal development. Please read through the two pdf files, below, and integrate the information provided to be able to answer the objectives listed. There are no Discussion Board assignments associated with this module at this time.

To guide your understanding of key concepts throughout this module on carcinogenisis, the materials have been developed in eight sections. Each of these sections has respective learning objectives, listed below, and are linked by section title:

Section 1 (Genetic and Developmental Toxicology, part 1: Overview):

To understand the basic concepts and terminology relevant to developmental toxicology
To understand the basic concept of genetic toxicity
To know the critical periods of susceptibility to developmental toxicants

Section 2 (Developmental Toxicolgy, part 2)

Understand the scope and potential causes of developmental toxicity
List major agents responsible for human developmental toxicity
Describe and understand Wilson's general principals of teratology
Understand the sequence and timing of human developmental events
List and understand potential mechanisms of teratogenesis
Understand what maternal conditions affect development and how they act in developmental toxicity