Dr. Kane's research interests include environmental pathology and toxicology of aquatic and marine organisms with emphasis on Chesapeake Bay fauna and captive fish species. Specific focus is placed on the use of sublethal indicators of contaminant and water quality stress on fish models. Endpoints relating to current research projects include: quantitative behavioral changes associated with reproduction and social dynamics in fish models; alterations in metabolic enzyme profiles; acoustic stress, and hearing and aging; histopathology; and mechanisms for species-selective toxicity and disease susceptibility. Additional interests include the use of dynamic outreach and teaching modules using interactive, computer-based multimedia.
Bachelor of Science. 1981. Cornell University. Aquatic and Marine Biology
Master of Science. 1985. The Ohio State University. Aquaculture / Aquatic Animal Health
Doctor of Philosophy. 1993. University of Maryland. Aquatic Toxicology / Pathobiology
Research Associate, Department of Pathology, University of Maryland School of Medicine, Baltimore, MD. 1986-1992
Envirovet Faculty, Program in Environmental Medicine and Toxicology, College of Veterinary Medicine, University of Illinois, Urbana, IL. 1993-2000.
Faculty Associate, Curriculum Research and Development, Office of Medical Education, University of Maryland School of Medicine, Baltimore, MD. 1994-2000.
Co-host, Third International Symposium on Aquatic Animal Health (ISAAH), 30 August through 3 September, 1998, Baltimore, Maryland.
Associate Professor, Department of Pathology, University of Maryland School of Medicine, Baltimore, MD. 1993-present.
Associate Professor, Department of Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD 1999-present.
Adjunct Associate Professor, Department of Art as Applied to Medicine, Johns Hopkins University, Baltimore, MD, 2004-present
Associate Research Scientist, Department of Veterinary Medicine, University of Maryland College Park, 2000-present.
Associate Profesor, Department of Epidemiology and Preventive Medcine, University of Maryland School of Medicine. 2004-present.
Director, Aquatic Pathobiology Program, University of Maryland, College of Agriculture and Natural Resources, Department of Veterinary Medicine. 2000-present.
Reviewer, Life Sciences. 1993-present.
Reviewer, Toxicologic Pathology. 1993-present.
Reviewer, American Cancer Society Institutional Resource Grant Review Committee, UMAB. 1994.
Ad Hoc Reviewer, Special Research Initiative Support (SRIS) Study Section #5, Designated Research Initiave Fund (DRIF) Committee, School of Medicine. 1994.
Editorial Assistant, Taylor and Francis Co. (Aquatic Toxicology, G. Rand, editor). 1995.
Graduate Fellowship Peer Panel Reviewer. Life Sciences Study Section, U.S. EPA, Wash., D.C. 1995.
Member and Reviewer, Institutional Animal Care and Use Committee, University of Maryland School of Medicine. 1995-present.
Book Review Editor, Aquatic Toxicology, Elsevier Publishing, The Netherlands. 1996-present.
Kane, A.S., R.O. Bennett and E.B. May. 1988. A flow-through dosing system to expose small aquatic organisms to varying pH, salinity and temperature. Water Research. 22:1339-1344.
Kane, A.S., R.O. Bennett and E.B. May. 1988. Effect of changing pH and salinity on Chesapeake Bay striped bass larvae. In: Understanding the Estuary, Advances in Chesapeake Bay Research, Chesapeake Research Consortium, Baltimore, MD. March 29-31. CRC Publication No. 129. United States Environmental Protection Agency CBP/TRS 24/88.
Kane, A.S., R.O. Bennett and E.B. May. 1990. Effect of hardness and salinity on striped bass larval survival. North American Journal of Fisheries Management 10(1):67-71.
Kane, A.S., R.O. Bennett, J.H. Resau, J. Cottrell, R. Reimschuessel, E.B. May, M. Streb, R. Hutchinson and M.M. Lipsky. 1991. Comparison of cell, tissue and whole organism bioassays to assess inorganic metals in the aquatic environment. Pages 409-424 in: Goldberg, A.M., editor. Alternative Methods in Toxicology, Volume 8. Mary Ann Liebert, Inc., NY.
Kane, A.S., M.W. Kahng, R. Reimschuessel, P.T. Nhamburo and M.M. Lipsky. Use of UDP-Glucuronyltransferase kinetics in vitro to assess relative toxicity of aqueous phenols in fish (Abstract). World Congress on Alternatives and Animal use in the Life Sciences, Baltimore, MD, November, 1993.
Kane, A.S., W.W. Day, R. Reimschuessel and M.M. Lipsky. 1993. TFM (3-trifluoromethyl-4-nitrophenol) toxicity and hepatic microsomal UDP-glucuronyltransferase activity in adult and larval bullfrogs. Aquatic Toxicology. 27:51-60.
Palace, V.P., J.F. Klavercamp and A.S. Kane. 1993. Phase I and Phase II metabolic enzyme activities and oxidative stress in lake trout from Lake Ontario (Abstract). Society of Environmental Toxicology and Chemistry, November 1993.
Reimschuessel, R. and A.S. Kane. 1993. A possible teleost model for polycystic kidney disease. Proceedings of the 24th Annual Conference of the International Association for Aquatic Animal Medicine, Chicago, IL. May, 1993.
Kane, A.S., M.W. Kahng, R. Reimschuessel and M.M. Lipsky. 1994. Comparative kinetics of TFM (3-trifluoromethyl-4-nitrophenol)-UDP-glucuronyltransferase in several species of fish. Transactions of the American Fisheries Society. 123:217-222.
Rokous, J., A.S. Kane and R. Reimschuessel. 1994. Renal regeneration and development following repeated gentimicin nephrotoxicosis. Proceedings of the 25th Annual Conference of the International Association of Aquatic Animal Medicine, Napa, CA, May 1994.
Kane, A.S. and S.L. Poynton. 1994. Desktop parasites: Application of computer-enhanced photomicroscopy. Proceedings of the 25th Annual Conference of the International Association of Aquatic Animal Medicine, Napa, CA, May 1994.
Kane, A.S., V. Emory, K. Moore, C. Råbergh and C. Ruegg. 1994. In vitro assessment of species-specific metabolic capacity in fish using liver tissue slices and microsomes (Abstract). Society of Environmental Toxicology and Chemistry, 15th annual meeting, Denver, CO.
Muhvich, A.G., R.T. Jones, A.S. Kane, R.S. Anderson and R. Reimschuessel. 1995. Effects of chronic copper exposure on macrophage chemiluminscent response and gill histology in goldfish (Crarassius auratus L.). Fish and Shellfish Immunology. 5:251-264
Kane, A.S. 1995. Computer-based training tool for fish anatomy and necropsy. Lab Animal. 47:48-50.
Kane, A.S. and S. Thohan. 1996. Use of fish hepatic tissue slices to evaluate species-specific metabolic capacity and alterations due to environmental exposure. Pages 371-391 in: G. Ostrander, editor. Methods in Aquatic Toxicology. Lewis Publishers, Boca Raton, FL.
Kane, A.S., S.V. Jacobson and R. Reimschuessel. 1996. Construction and use of a large scale dosing system to expose fish to waterborne toxicants. Pages 589-607 in: G. Ostrander, editor. Methods in Aquatic Toxicology. Lewis Publishers, Boca Raton, FL.
Kane, A.S. 1996. FishGuts: A Multimedia Guide to the Art and Science of Fish Anatomy, Health and Necropsy. "FishGuts is an interactive fish necropsy and histopathology computer training program, distributed by APC Press (for more information, contact the author).
Kane, A.S. 1996. Multimedia update: Advances in computer-based applications relevant to fish and fish health. Annual Review of Fish Disease, 1995 volume, 5:79-84.
Råbergh, C.M., A.S. Kane, R. Reimschuessel and M.M. Lipsky. 1995. Viability and induction of tyrosine aminotransferase in rainbow trout hepatocytes cultured on laminin and polylysine in a serum-free medium. Methods in Cell Science 17:207-215.
Kane, A.S., J.F. González and R. Reimschuessel. 1996. Fish and amphibian models used in toxicology. Lab Animal. 25(6):33-38
Trifillis, A.L., Del Valle, M. Lipsky, X. Cui, C. Ruegg and A.S. Kane. 1998. Cultured rabbit renal proximal straight tubular cells are more susceptible to mercuric chloride than convoluted tubular cells. Renal Toxicology. 11(2):133-138.
Jiang, Q., L. DeTolla, N. Van Roojien, I.S. Singh, B. Fitzgerald, M.M. Lipsky, A.S. Kane, A.S. Cross and J.D. Hasday. 1998. Febrile-range temperature modifies early systemic tumor necrosis factor alpha expression in mice challenged with bacterial endotoxin. Infection and Immunity. 67(4):1539-1546.
Kane, A.S., J.E. Whaley, J. Paul and R. Reimschuessel. 1977. Angler Outreach for Fish Pathology Studies at a U.S. Army Superfund Site. Proceedings of the International Association for Aquatic Animal Medicine. 28:95-103.
Kane, A.S., S. Thohan and M. Weiner. 1998. Tissue Slice Technology for Assessing Alterations in Fish Hepatic Phase I and Phase II XME Activity. Marine Environmental Research. 46:61-65.
Kane, A.S., Oldach, D. and R. Reimschuessel. 1998. Fish Lesions in Chesapeake Bay: Pfiesteria-like Dinoflagellates and Other Etiologies. Maryland Medical Journal. 47(3):106-112.
McDowell, A.G., A.S. Kane, and R. Reimschuessel. 1999. Chronic renal damage in largemouth bass, Micropterus salmoides, due to a monogenetic trematode infection. Pages 25-27 in: Proceedings of the International Association of Aquatic Animal Medicine, Boston, MA.
Jacobson, S.V., M. Trucksis, A.S. Kane and R. Reimschuessel. 1999. Superoxide production in Mycobacterium-stimulated goldfish (Crassius auratus) phagocytes following copper exposure. J. Vet. Res. 60(6): 669-675.
Talaat, A.M., Trucksis, M., A.S. Kane and R. Reimschuessel. 1999. Pathogenicity of Mycobacterium fortuitum and mycobacterium smegmatis to Goldfish (Crassius auratus) model. Veterinary Microbiology 66:151-164.
Yonkos, L.T. and A.S. Kane. 1999. Development of a digital atlas of fathead minnow histology. Lab Animal. 28(2):39-42. Link to: Atlas on the web.
González, J., P.Del Valle, S. Thohan and A.S. Kane. 2000. Effects of waterborne nitrite on phase I-II biotransformation in channel catfish. Marine Environmental Research 50: 29-32.
Kane, A.S., M.J. Dykstra, E.J. Noga, R. Reimschuessel, A. Baya, C. Driscoll and H.W. Paerl. 2000. Observations and reporting of estuarine finfish lesions: Pfiesteria and other etiologies. Marine Environmental Research. 50: 473-477.
Dykstra, M.J. and A.S. Kane. 2000. Pfiesteria piscicida and ulcerative mycosis of Atlantic menhaden; current status of understanding. Journal of Aquatic Animal Health. 12:18-25.
Yonkos, L.T., D.J. Fisher, D.A. Wright and A.S. Kane. 2000. Pathology in fathead minnows (Pimephales promelas) exposed to chlorine dioxide and chlorite. Marine Environmental Research 50:267-271.
Salice C.J., Rokous J.S., Kane A.S., Reimschuessel R. 2001. New nephron development in goldfish (Carassius auratus) kidneys following repeated gentamicin nephrotoxicosis. Comparative Medicine 52:56-59, 2001.
Thohan, S., Zurich, ML-C., Chung, H., Weiner, M., Kane, A.S. and Rosen, GM. 2001. Tissue Slices Revisited: Evaluation and Development of a Short-Term Incubation for Integrated Drug Metabolism. Drug Metabolism and Disposition, 29:1337-1342.
van der Schalie, W.H., Shedd, T., Widder, M., Kane, A.S., Silbergeld, E., Reimschuessel, R., Poli, M., Sarabun, C., Burkholder, J., Glasgow, H.. 2001. Real-time monitoring for toxicity caused by harmful algal blooms and other water quality perturbations. US Environmental Protection Agency EPA/600/R-01/103, November 2001.
Del Valle, P.L., Trifillis, A., Ruegg, C.E. and Kane, A.S. 2002. Characterization of glucose transport by cultured rabbit kidney proximal convoluted and proximal straight tubule cells. In Vitro: Cellular and Developmental Biology-Animal 38(4):218-227.
Reimschuessel R., C.M. Gieseker, C. Driscoll, A. Baya, A.S. Kane, V. S. Blazer, J.J. Evans, M. L. Kent, J.D.W. Moran, and S.L. Poynton. 2003. Myxosporean plasmodial infection, associated with ulcerative lesions in young-of-the-year Atlantic menhaden Brevoortia tyrannus (Latrobe) (Clupeidae) in a tributary of the Chesapeake Bay, and possible links to Kudoa clupeidae. Diseases of Aquatic Organisms, 53:143-166.
Choich, J., Salierno, JD., Silbergeld, E.K., and Kane, A.S. 2004. Altered brain activity in brevetoxin-exposed bluegill, Lepomis macrochirus, visualized using in vivo 14C 2-deoxyglucose labeling. Environmental Research, 94:192-197.
Smith, M.E., Kane, A.S. and Popper, A.N. 2004. Noise-induced stress response and hearing loss in goldfish (Carassius auratus). Journal of Experimental Biology, 207:3591-3602.
Smith, M.E., Kane, A.S. and Popper, A.N. 2004. Acoustical stress and hearing sensitivity in fishes: Does the linear threshold shift hypothesis hold water? Journal of Experimental Biology,207:3591-3602.
Stine, C.B., Smith, D.L., Vogelbein, W.K., Harshbarger, J.C., Gudla, P.R., Lipsky, M.L., and Kane, A.S. 2004. Morphometry of hepatic neoplasms and altered foci in killifish, Fundulus heteroclitus. Toxicologic Pathology 32:4 375-383.
Kane, A.S., Salierno, J.D., Gipson, G.T., Molteno, T., and , Hunter, C. 2004. Novel video-based movement analysis system to quantify behavioral responses of fish. Water Research. 38:3993-4001.
Salierno, J.D., Shields, J.D., Snyder, N.S., Murphy, A.Z. and Kane, A.S. 2004. Altered Fos expression as a biomarker of neuronal stress associated with harmful algal bloom exposure in mummichog, Fundulus heteroclitus. Harmful Algae 3:245.
Kane, A.S., Salierno, J.D. and Brewer, S.K. 2004. Fish models in behavioral toxicology: automated techniques, updates and perspectives. In Ostrander, G.K., ed. Methods in Aquatic Toxicology, Volume 2. Lewis Publishers, Boca Raton, FL.
Kane, A.S. 2005. Striped Bass Stock Health Assessment: Mycobacteriosis prevalence and distribution. Proceedings of the 2005 Chesapeake Bay Fisheries Research Symposium, pages 17-22. Published by NOAA Chesapeake Bay Office, Annapolis, MD.
Stine, C.B., Baya, A.M., Salierno, J.D., Kollner, M. and Kane, A.S. 2005. Mycobacterial infection in laboratory-maintained menhaden (Brevoortia tyrannus). Journal of Aquatic Animal Health 17(4):380-385.
Kane, A.S., Hungerford, L, Stine, C.B., Matsche, M., Driscoll, C.P., Jacobs, J.M. and Baya, A.M. 2006. Mycobacteriosis in Chesapeake Bay fishes: Perspectives and questions. Pages 20-22 in Ottinger, C.A., and Jacobs, J.M., editors. USGS/NOAA Workshop on Mycobacteriosis in Striped Bass, May 7-10, 2006, Annapolis, Maryland: U.S. Geological Survey Scientific Investigations Report 2006-5214 / National Oceanic and Atmospheric Administration Technical Memorandum NOS NCCOS 41, 42 p.
Lauer, L.E., McCarthy, M.M., Jong, J. and Kane, A.S. 2006. Sex differences in neuronal morphology in the killifish hypothalamus. Brain Research, 1070:145-149.
Salierno, J.D., Gipson, G.T. and Kane, A.S. 2007. Quantitative movement analysis of social behavior in mummichog, Fundulus heteroclitus. Journal of Ethology (In Press).
Kane, A.S., Stine, C.B., Hungerford, L., Matsche, M., Driscoll, C.P. and Baya, A.M. 2007. Mycobacteria as Environmental Portent in Chesapeake Bay Fishes. Emerging and Infectious Diseases 13(2) February 2007.
"Alterations in hepatic biotransformation enzymes at contaminated sites in the northern Chesapeake Bay." Collaborators: Mary L. Haasch (MS State University), Sanjeev Thohan (AstraZenica), and Renate Reimschuessel and Badar Shaikh (USFDA, Center for Veterinary Medicine)
"Fish pathology studies and angeler outreach at a U.S. Army Superfund site." Collaborators: Renate Reimschuessel , Janey Whaley; and John Paul, U.S. Army Directorate for Health, Safety and Environment.
"Development of a histological atlas to illustrate normal tissue conditions of the fathead minnow." Collaborators: Daniel Fisher and Lance Yonkos (Wye Research Center).
"Alterations in sex-linked fish brain neuronal anatomy due to environmental stress." Collaborator: Margaret McCarthy (Department of Physiology, UMB).
"Tumors prevalence and presentation in Chesapeake Bay fish." Collaborators: John Harshbarger (Registry of Tumors in Lower Animals, Department of Pathology, George Washington University Medical Center), Wolfgang Vogelbein (Virginia Institute of Marine Science).
"Responses to acoustic stress in fish." Collaborators: Arthur Popper and Michael Smith (Bioacoustics Laboratory, Univ of Maryland, Department of Biology).
"Mycobacteriosis in Chesapeake Bay striped bass." Collaborators: Ana Baya (Maryland Department of Agriculture Fish Health Laboratory); Renate Reimschuessel (FDA/CVM); Cindy Driscoll, Mark Matche, and Larry Piper (Maryland Department of Natural Resources); John Jabobs (NOAA); Laura Hungerford (UM Dept Epidemiology and Preventive Medicine); and Cindy Stine (graduate student).
"Altered Fos expression in fish brains associated with exposure to different biochemical and physical stressors." Collaborators: Anne Murphy, Natalie Snyder and Jim Salierno.
"Facilitating Needed Drug Approvals for Aquaculture: In Vitro Metabolic Profiles to Characterize and Predict Drug Residues in Finfish." Collaborators: Renate Reimschuessel and Badar Shaikh (US FDA), and Jaime Gonzalez (grad student).
"Alterations in reproductive capacity associated with complex mixtures of endocrine disrupting compounds." Collaborators: Dan Fisher, Lance Yonkos, Ray Morgan.
"Gene interactions between environmental mycobacteria." Mamuka Kotetishvili and Laura Hungerford (UM Medical School, Department of Epidemiology & Preventitive Medicine).