NURS 735 Applied Toxicology (3 credits)
(Temp 2002 Registration Info: NURS 678; Section 1; CRN #20916)
Spring semester, 2002
Wednesdays, 2:00-4:50 PM.
School of Nursing, Room 460
655 West Baltimore Street
University of Maryland, Baltimore, MD 21201
Last updated: 10 April 2002



[Weekly Topics & Assigned Readings] [ Other Materials & Readings] [ Grading, Academic Conduct, Weather Cancellations]

Course Description:
Applied Toxicology will survey the principles of toxicology that pertain to human health and the environment. Course content will include an historical background of toxicology; principles of absorption, distribution, metabolism and elimination; effects of toxic agents, food additives and pollutants, with effects on general and susceptible populations; risk communication; outreach; and the integration of these principles into public health practice. The course is intended to empower students with knowledge and working insight into toxic environmental hazards that may affect the diverse human populations that are served by community health nurses and other public health professionals. Comparative effects on other animal groupings will also be covered. A multi-disciplinary, team teaching approach will be used to meet the course objectives. NURS 735 is a required course in the Community Environmental Health Nursing track, an emphasis within the graduate Community Health Nursing track at the School of Nursing. This new track is being developed with a three-year grant from the USDHHS, HRSA in response to the national need to prepare an essential cadre of nursing leaders for the critical and emerging issues in environmental health.

Coursemasters:
Barbara Sattler, RN, DrPH
Director, Environmental Health Education Center
UMB School of Nursing
Baltimore, MD
bsattler@son.umaryland.edu
Andrew S. Kane, Ph.D.
UM Toxicology Program
Department of Epidemiology & Preventive Medicine;
Director, Aquatic Pathobiology Center
College Park, MD
akane@umaryland.edu

 

Textbook:
Casarette & Doull's TOXICOLOGY, The Basic Science of Poisons,
6th Edition. CD Klaassen, Editor. 2001. McGraw Hill.
RA1211.C296 2001. Referred to as 'C&D' in reading assignments.

 

Weekly Class Topics, Speakers and Required Readings (check updates regularly for required readings).
Class presentation materials can be viewed by clicking on the topic link.

 DATE TOPIC AND SPEAKERS READINGS (C&D, NLM ToxTutorials, Other)
 Jan 23 Background & Principals of Toxicology (AS Kane) C&D ch 2
dose and dose-response review
factors affecting toxicity
ADME concepts
chemical concepts
 Jan 30 Target Organ Anatomy & Susceptibility; Metabolism (AS Kane) C&D ch 6
cell physiology review
organ systems review
target organs
target organ toxicity
biotransformation
enzymes; phase I & II reactions
factors affecting biotransformation
 Feb 6 Absorption, Distribution & Excretion (C Willmore) C&D ch 5
absorption (general)
GI absorption
respiratory absorption
dermal absorption
other exposure routes
distribution
blood-brain barrier
influence of expousure route on distribution
compartment models
fat & bone storage
excretion (general)
urinary excretion
fecal excretion
pulmonary & other routes of excretion
Feb 13
Mutagenesis & Developmental Toxicology (ML Lipsky)
Information Resources: on line & in print
(Cynthia Phyillaier, Diane Fuller)
C&D ch 10
 Feb 20 Carcinogenesis (ML Lipsky) C&D ch 8
 Feb 27 Pesticides; Metals (K Squibb) C&D ch 22, 23
 Mar 6 Metals; Mid-term exam (K Squibb) .
 Mar 13 Organics, Solvents and Vapors (K Squibb) C&D 24
 Mar 20
Risk Assessment (A Sergeant);
Animal and Plant Toxins (JG Morris)
C&D ch 4;
C&D ch 26, 27
Reference websites on natural toxins
 Mar 27 Spring Break - no class Suggested references on
Food Additives available on-line
 Apl 3 Presentation and Outreach Skills (AS Kane);
Occupational Toxicology:ppt presentation & handout (S. Amr)
C&D 33
 Apl 10 Regulatory Toxicology (R Steinzor) C&D ch 34; A Civil Action (book or video)
 Apl 17 Clinical Toxicology: ppt presentation & handout (W. Klein-Schwartz);
Endocrine Disruption (J Flaws)
C&D 32
Reprints from Dr. Flaws
 Apl 24 Risk Communication (R Eskin);
Student presentations & critiques (AS Kane)
See websites provided by Dr. Eskin
 May 1 Final exam; Course Evaluation .


Other course materials & readings:

Internet references associated with Dr. Morris' March 20th lecture on animal and plant toxins (good reference materials):

Foodborne pathogenic microorganisms and natural toxins handbook (FDA Center for Food Safety & Applied Nutrition)

Organisms that can bug you (Partnership for Food Safety)

Food safety education: Foodborne illness & what consumers need to know (FDA Center for Food Safety & Applied Nutrition)

 

Internet references associated with Dr. Eskin's April 24th Lecture on Risk Communication:
(note that the second reference, ATSDR risk communication primer, is a required reading.

Recommendations To Improve Health Risk Communication, A Report on Case Studies in Health Risk Communication.
Environmental Health Policy Committee, Subcommittee on Risk Communication and Education,
DHHS, November 1994
http://web.health.gov/environment/Recomm/reportTOC.htm

ATSDR risk communication primer (required)
http://www.atsdr.cdc.gov/HEC/primer.html

Risk communication in a democratic society, annotated bibliography
http://www.fplc.edu/risk/demindx.htm

Technical risk in the mass media, annotated bibliography
http://www.fplc.edu/risk/medIndx.htm

Comparing risks thoughtfully
http://www.fplc.edu/RISK/vol6/summer/Fischhof.htm

Ranking risks
http://www.fplc.edu/RISK/vol6/summer/Fischhof.htm

Social management of risks
http://www.fplc.edu/RISK/vol7/fall/fritzsch.htm

from "A Case Study of Health Risk Communication:
What the Public Wants and What it Gets"
http://www.fplc.edu/risk/vol5/winter/trauth.htm

 

Internet references associated with Food Additives (good reference materials; not comprehensive):

A primer on food additives (FDA/IFIC brochure; January 1992)
http://vm.cfsan.fda.gov/~lrd/foodaddi.html

A fresh look at food preservatives (FDA Consumer, October 1993)
http://vm.cfsan.fda.gov/~dms/fdpreser.html

Gateway to government food safety information
http://www.foodsafety.gov/

Pesticides, Metals, Chemical Contaminants & Natural Toxins in Food (USFDA CFSAN publication)
http://www.cfsan.fda.gov/~lrd/pestadd.html

 


Additional Toxicology References:
Clayson, David. (2001). Toxicological carcinogenosis. Boca Raton, Florida: Lewis Publishers. RC268.6.C56 2001
Morton & Lippmann (Ed.). (2000). Environmental toxicants: Human exposures and their health effects (2nd ed.). New York: Wiley & Interscience. RA565.E58 2000
Ottoboni, M. Alice. (1991) The dose makes the poison: A plain-language guide to toxicology (2nd ed.). New York: Van Nostrand. RA1213.088 1991
Paul, Maureen. (1993). Occupational and environmental reproductive hazards: A guide for clinicians. Baltimore, MD: Williams & Wilkins. RA1224.2.033 1993
Phillip, L. (Ed.). (2000). Principles of toxicology: Environmental and industrial applications. New York: Wiley. RA1211.P746 2000
Schettler, T., Solomon, & Valenti. (1999). Generations at risk: Reproductive health and the environment. Cambridge, MA: MIT Press. RA1224.2.G46 1999
World Health Organization. (2001). Neurotoxicity risk assessment for human health. Geneva. RC347.5. N482 2001


Grading Criteria:
Class and Quiz Participation 20%
Risk Communication (student presentation) 20%
Mid-term Examination 30%
Final Examination 30%
  100%

The 'risk communication' portion of the grade will be based on preparation, effort and delivery of an outreach presentation, based on guidelines offered during the April 3rd lecture. Students should consider potential topics early in the semester and discuss them with the instructor to facilitate appropriate preparation and subject matter focus.


Academic Integrity and Conduct:
Students are referred to the University of Maryland School of Nursing Student Handbook for all policies regarding academic integrity and conduct. These include the University of Maryland System Policy on Faculty, Students and Institutional Rights and Responsibilities for Academic Integrity, the School of Nursing Statement of Student Rights and Responsibilities, and the University of Maryland Graduate Policies and Procedures for Academic Misconduct.

Weather-related Cancellations:
The policy in the University of Maryland School of Nursing Handbook regarding weather-related cancellations will be followed. Check this website for updates or changes in scheduling.


[Contact Webmaster]